The MTHFR gene is responsible for the enzyme that supports glutathione production. Fibromyalgia, meanwhile, is a painful and chronic condition that is sometimes associated with genetics. How are they connected? Find out below.
The Link Between MTHFR and Fibromyalgia
In This Article:
- What is MTHFR?
- What is Fibromyalgia?
- How are MTHFR and Fibromyalgia Linked?
- Is There a Way to Address Fibromyalgia?
What is MTHFR?
According to the U.S. National Library of Medicine, “The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins.”
“What this enzyme does is work on the path called methylation. This is the conversion basically from B12 into the active form of B12 and various other components that are made from it. This includes glutathione,” Dr. Stephen Smith explained in the video.
When the MTHFR mutates or has a deficiency, it leads to poor methylation cycle and enzyme production. Dr. Smith said there are about 50 variations in this anomaly. The two most common are, C677T and A1298C, which are also the variants he usually measures.
He said, “667 and 1298 cause quite a bit of a problem. They’re fairly common. Thirty percent of the population has a double anomaly, meaning both 667 and 1298. And about forty percent has a single [anomaly].”
Note: The number refers to the base of the DNA.
What is Fibromyalgia?
There is a need to understand what fibromyalgia is before delving into its relationship with MTHFR.
Fibromyalgia Syndrome (FMS) is a chronic, painful, and sometimes disabling condition that affects the muscles and tissues. The main symptom is the widespread musculoskeletal pain, felt above and below the waist, including both sides of the body. Other symptoms are:
- Fatigue, despite having slept for hours
- Trouble sleeping
- Memory and concentration problems
- Numbness and tingling hands and feet
The exact cause of fibromyalgia is not known but there are some risk factors considered:
- Autoimmune disorders
- Injury and trauma
- Psychological and emotional stress
How are MTHFR and Fibromyalgia Linked?
#MTHFR – kinda looks like a curse word right!? Promise I'm not using bad language. 😉 More than half of us have this, and if you or your spouse have it, you likely have passed it on to your kiddos too, but what IS it!? What does it look like?! Here’s a short list of how MTHFR can present in health issues: 💥Vascular disease 💥Blood clots 💥Respiratory issues 💥Miscarriages 💥Neural Tube Defects 💥Down Syndrome 💥Anxiety 💥Depression 💥Fatigue For the estimated 60% of people affected by this gene mutation, a curse is exactly what it can feel like!! Most don’t even KNOW that they have this gene mutation that causes an inability to process certain forms of key nutrients, and makes it very difficult for their body to detox. People with the MTHFR mutation are unable to “methylate” ingredients like Folic Acid, as well as certain B vitamins. Instead, these ingredients turn TOXIC in their body. Methylation is a very complex thing but simply put, it’s the ability to process toxins and hormones. When the methylation process is inhibited for any reason, Glutathione levels drop, making the body more susceptible to oxidative stress, and far less tolerant to toxins. This lack of detoxification can lead to all kinds of behavioral, mental, and even physical illnesses or disabilities. The methylation cycle is tied directly to our serotonin (happy hormone) and dopamine (reward and pleasure neurotransmitter) levels. Individuals with MTHFR often need higher doses of Vitamin D as well because they lack the ability to absorb it properly. It’s crucial that they find a good methylated multi-vitamin, as well as a probiotic, and omega supplement that have bio-available nutrients they can readily and quickly absorb. The best news: methylated vitamins and nutrients are beneficial for EVERYONE, even if you DON’T have any form of genetic mutation…. no one is excluded, yet everyone is covered!! 🌈 #letschat #doyouoryourkidshavethisgene #myCHILDRENAndADULTvitaminismethylated
Again, mutation or deficiency in the MTHFR affects methylation and enzyme production. When these function poorly, it negatively affects your glutathione levels and the whole detoxification process. This leads to many problems in your body like causing chronic diseases.
Dr. Smith stated, “If you have fibromyalgia, autism, and ADD, you probably have a glutathione deficiency.
Glutathione, as the primary antioxidant, removes toxins. It also helps reduce oxidative stress which is like ‘rusting’ in the body according to Dr. Smith.
He said, “When our bodies make energy, they produce byproducts and some of these are toxic and they need to be reduced. Glutathione’s job is to do this. So, it’s the primary protectant in our body. If you don’t have enough of it, then you are more susceptible to chronic diseases.”
Is There a Way to Address Fibromyalgia?
There are many approaches to addressing fibromyalgia, but in this article, we discuss only one. Looking at how the condition is related to MTHFR, Dr. Smith suggests improving glutathione levels to help manage fibromyalgia.
He said, “If you have issues with fibromyalgia, one of the first things you want to do is see if you can get your glutathione levels measured. This is not an easy test to get done. You have to go to a third-party lab like Lab-Corp, or the one we use.”
“The other thing you want to do is get your MTHFR status.”
You need the information to determine the supplements that can raise your glutathione levels. A supplement with a combination of methyl B12 and l-methylfolate may help boost cognitive function, energy, and memory, which are all associated with fibromyalgia.
Learn more about MTHFR and fibromyalgia from Dr. Smith in this video:
The relationship between MTHFR and fibromyalgia is not all too complicated. What you must understand is how MTHFR deficiency causes methylation block and affects glutathione production. When glutathione levels are low, you become susceptible to chronic conditions like fibromyalgia.
What are your thoughts on glutathione boost? Let us know in the comments section.